--- title: Ordaos | AI-driven Protein Design --- [Skip to content](https://www.carbonado.holdings#main) [![Ordaōs — home](https://www.carbonado.holdings/hubfs/raw_assets/public/carbonado-theme-preview/images/logo-ordaos-reverse.svg)](https://www.carbonado.holdings/?hsLang=en) - [Home](https://www.carbonado.holdings/) - [Team](https://www.carbonado.holdings/team) - [News](https://www.carbonado.holdings/news) - [Events](https://www.carbonado.holdings/events) - [Partner](https://www.carbonado.holdings/partner) [Contact us](https://www.carbonado.holdings/contact?hsLang=en) - [Home](https://www.carbonado.holdings/) - [Team](https://www.carbonado.holdings/team) - [News](https://www.carbonado.holdings/news) - [Events](https://www.carbonado.holdings/events) - [Partner](https://www.carbonado.holdings/partner) [Contact us](https://www.carbonado.holdings/contact?hsLang=en) # Lab-in-the-loop AI platform for biologics discovery Our Platform ## Rapidly discover high-value small proteins 1 ### Multi-agentic LLM system 2 ### Rapid, lab-in-the-loop data generation 3 ### High-value, small protein candidates 200 high-potential mini-proteins per round Next Step 1\. Multi-agentic LLM system ## Committees of independent AI agents cross-check and rigorously screen potential proteins ### Our AI model generates a protein design AI assembles billions of amino acids into novel mini-proteins ### Will it bind to the target? Binding affinity Binding kinetics Binding durability Off-target interactions ### Is it stable? Thermal stability Chemical stability Structural integrity Freeze-thaw resilience Oxidation resistance Shear stress tolerance ### Is it toxic? Immunogenicity Cytotoxicity Accumulation risk Allergenic potential Metabolite toxicity Interaction with microbiome Genotoxicity Reproductive toxicity ### Is it soluble? Aggregation propensity Hydrophobicity Isoelectric point Formulation fit 200 high-potential mini-proteins per round 2\. Rapid Lab-in-the-loop Data Generation ## We rapidly make and test each protein 5 days ### We start by making the 200 proteins in our proprietary cell-free protein expression system ### Run each protein through ten different lab tests ### Map the results to find hits 200150100500 2–50% Hit rate for zero-shot design 80% Hit rate on future iterations 3\. High value, small protein candidates ## Protein hits within four iterations Segment Indication Design Pre-Clinical IND-Enabling Phase I Phase II Metabolism Metabolic Disorder Infectious Disease NTM Ag Chemical Replacement Protein Herbicides Interested or engaged partner Our Difference: ## Our platform doesn’t just find winners, it designs better proteins from the start Higher success rates Broad market applications More stable Faster development Better drug delivery ## Case studies: ### De Novo drug discovery Designing de novo miniPRO™ binders to HER2 with generative AI resulting in leads that are 93% smaller than standard of care within weeks. [Learn more](https://www.carbonado.holdings/hubfs/AACR2022%20Poster%20%238181.pdf?hsLang=en) ### Optimization Optimizing single domain VHH antibodies against SARS-CoV-2 S1 with generative AI, resulting in therapeutic candidates that overcome evolutionary escape. [Learn more](https://www.carbonado.holdings/hubfs/AETposter2022_Ordaos.pdf?hsLang=en) ## We’re a science-first organization Explore our Research [![pegs-cell-free-resized-image](https://www.carbonado.holdings/hubfs/pegs-cell-free-resized-image.webp)](https://www.carbonado.holdings/hubfs/pegs%20cell-free%20expression%20(1).pdf?hsLang=en) Development of a Nanobody Producibility Model using High-throughput Cell-Free Expression and Purification (PEGS 2026) Latest from Our Blog No posts published yet. ## Who We Are At Ordaōs, people are at the heart of every breakthrough. We bring together diverse teams in a collaborative, mission-driven environment, united by a shared goal: designing better biologics to ease patient suffering. Meet the Team ## Meet the minds shaping life-saving treatments ![David Longo](https://www.carbonado.holdings/hubfs/Dave%20headshot%20(1).webp) **David Longo** Chief Executive Officer ![Max Bluestone](https://www.carbonado.holdings/hubfs/Max-1.webp) **Max Bluestone** VP, ML & AI ![John Janczy](https://www.carbonado.holdings/hubfs/John-1.webp) **John Janczy** Director, Emerging Programs ![Daniel Cohen](https://www.carbonado.holdings/hubfs/Daniel-1.webp) **Daniel Cohen** Group Lead, Protein Production ![Sasen Efrem](https://www.carbonado.holdings/hubfs/Sasen_Gray-1.webp) **Sasen Efrem** Group Lead, Biophysics ![Jeff LaFrence](https://www.carbonado.holdings/hubfs/Jeff-1.webp) **Jeff LaFrence** Senior Scientist, Bioprocess ![Lahari Gorantla](https://www.carbonado.holdings/hubfs/Lahari-1-1.webp) **Lahari Gorantla** Senior Computational Biologist ![Luke Martin](https://www.carbonado.holdings/hubfs/Luke-1.webp) **Luke Martin** Senior AI Scientist ![Alena Romanova](https://www.carbonado.holdings/hubfs/Alena-1.webp) **Alena Romanova** Senior Scientist ![Jonas Schemm](https://www.carbonado.holdings/hubfs/Jonas-1.webp) **Jonas Schemm** Scientist II ![Ilya Dementyev](https://www.carbonado.holdings/hubfs/Ilya-1.webp) **Ilya Dementyev** Associate Scientist ![Jasmine Choi](https://www.carbonado.holdings/hubfs/Jasmine-1.webp) **Jasmine Choi** Associate Scientist, Lab Manager ## Ordaōs in the Press ### [![](https://www.carbonado.holdings/hubfs/Screenshot%202026-09-15%20114230.png) July 29th, 2026 Quercus Biosolutions closes $5m seed round to target resistant weeds with designer proteins](https://agfundernews.com/exclusive-quercus-biosolutions-closes-5m-seed-round-to-target-resistant-weeds-with-designer-proteins) ## Let’s talk about working together [Contact us](https://www.carbonado.holdings#hs_cos_wrapper_widget_1790007564116) “ > You accomplished in four days what took us two years to accomplish. ![](https://www.carbonado.holdings/hubfs/phh8-re-resized-image.webp) Dr. Philip Howe, PhD Chair, Department of Chemistry, Medical University of South Carolina ![Ordaōs](https://www.carbonado.holdings/hubfs/raw_assets/public/carbonado-theme-preview/images/logo-ordaos-reverse.svg) Company [Home](https://www.carbonado.holdings/?hsLang=en) [News](https://www.carbonado.holdings/news?hsLang=en) [Team](https://www.carbonado.holdings/team?hsLang=en) [Events](https://www.carbonado.holdings/events?hsLang=en) Get in touch [Contact Us](https://www.carbonado.holdings/contact?hsLang=en) [Careers](https://www.carbonado.holdings/careers?hsLang=en) [Partner](https://www.carbonado.holdings/partner?hsLang=en) Connect 45-18 Court Sq W Ste 101, Long Island City, NY 11101, USA [Privacy Policy](https://www.carbonado.holdings/privacy-policy?hsLang=en) [Terms of Use](https://www.carbonado.holdings/terms-of-use?hsLang=en) Copyright 2026 Carbonado Holdings, Inc. d/b/a Ordaōs